Chemical and Biochemical EngineeringWestern Engineering

Publications

Refereed Journal Publications (in last 5 years):

  1. Young SA, Sherman SE, Cooper TT, Brown C, Anjum F, Hess DA, Flynn LE*, and Amsden BG* (* co- corresponding authors). (2018) Mechanically robust injectable scaffolds for intramuscular stem cell delivery and cytokine release. Biomaterials, https://doi.org/10.1016/j.biomaterials.2018.01.008. Accepted Jan. 3, 2018, published online ahead of print. (*Biomaterials ISI Impact Factor 8.402, top journal in the field)

  2. Robb KP, Shridhar A, and Flynn LE*. (2017) Decellularized matrices as cell-instructive scaffolds to guide tissue-specific regeneration. ACS Biomaterials Science & Engineering. doi:10.1021/acsbiomaterials.7b00619. (Review)

  3. Kuljanin M, Brown CFC, Raleigh MJ, Lajoie GA*, and Flynn LE*. (2017). Collagenase treatment enhances proteomic coverage of low-abundance proteins in decellularized matrix bioscaffolds. Biomaterials, 144, 130-43.

  4. Yu C, Kornmuller A, Brown CFC, Hoare T, and Flynn LE*. (2017) Decellularized adipose tissue microcarriers as a dynamic culture platform for human adipose-derived stem/stromal cell expansion. Biomaterials, 120, 66-80.

  5. Kornmuller A, Brown CFC, Yu C, and Flynn LE*. (2017) Fabrication of extracellular matrix-derived foams and microcarriers as tissue-specific cell culture and delivery platforms. Journal of Visualized Experiments (JoVE), e55436: doi:10.3791/55436.

  6. Anjum F, Carroll A, Young SA, Flynn LE, and Amsden BG*. (2017) Tough, semi-synthetic hydrogels for adipose-derived stem cell delivery for chondral repair. Macromolecular Bioscience, 17(5): 1600373.

  7. Haddad SMM, Omidi E, Flynn LE, and Samani A*. (2016) Comparative biomechanical study of using decellularized human adipose tissues and hyaluronic acid fillers for post-mastectomy and post-lumpectomy breast reconstruction. Journal of the Mechanical Behavior of Biomedical Materials, 57:235-45.

  8. Russo V, Omidi E, Samani A, Hamilton A, and Flynn LE*. (2015) Porous ventricular extracellular matrix- derived foams as a platform for cardiac cell culture. BioResearch Open Access, 4(1) 374-88.

  9. Han TTY, Toutounji S, Amsden BG, and Flynn LE*. (2015). Adipose-derived stromal cells mediate in vivo adipogenesis, angiogenesis and inflammation in decellularized adipose tissue bioscaffolds. Biomaterials, 72, 125-37.

  10. Brown CFC, Yan J, Han TTY, Maracek D, Amsden BG, and Flynn LE*. (2015) Effect of decellularized adipose tissue particle size on adipose-derived stem cell proliferation and adipogenic differentiation in composite methacrylated chondroitin sulphate hydrogels. Biomedical Materials. 10(4), 045010.

  11. Zhao Y, Waldman SD, and Flynn LE*. (2015) Multilineage co-culture of adipose-derived stem cells for tissue engineering. Journal of Tissue Engineering and Regenerative Medicine, 9, 826-837.

  12. Omidi E, Fuetterer L, Mousavi SR, Armstrong RC, Flynn LE, and Samani A*. (2014) Characterization and assessment of hyperelastic and elastic properties of decellularized human adipose tissues. Journal of Biomechanics 47(15), 3657-3663.

  13. Russo V, Young S, Hamilton GA, Amsden BG, and Flynn LE*. (2014) Mesenchymal stem cell delivery strategies to promote cardiac regeneration following ischemic injury. Biomaterials 35(13), 3956-74.

  14. Russo V, Yu C, Belliveau P, Hamilton GA, and Flynn LE*. (2014) Comparison of human adipose-derived stem cells isolated from subcutaneous, omental and intrathoracic adipose tissue depots for regenerative applications. Stem Cells Translational Medicine, 3, 206-214.

  15. Cheung HK, Han T, Maracek, D, Watkins JF, Amsden BG, and Flynn LE*. (2014) Composite photocrosslinkable hydrogel scaffolds incorporating decellularized adipose tissue for soft tissue engineering with adipose-derived stem cells. Biomaterials 35(6), 1914-23.

  16. Yu C, Young S, Russo V, Amsden BG, and Flynn LE*. (2013) Techniques for the isolation of high quality RNA from cells encapsulated in chitosan hydrogels. Tissue Engineering Part C Methods 19(11), 829-38.

  17. Yu C, Bianco J, Brown C, Fuetterer L, Watkins JF, Samani A, and Flynn LE*. (2013) Porous decellularized adipose tissue foams for soft tissue regeneration. Biomaterials 34(13), 3290-302.

  18. Bowey K, Swift B, Flynn LE, and Neufeld RJ*. (2013) Characterization of biologically active insulin-loaded microparticles prepared by spray drying. Drug Development and Industrial Pharmacy 39(3), 457-65.

  19. Zhao Y, Waldman SD, and Flynn LE*. (2012) Multilineage co-culture of adipose-derived stem cells for tissue engineering. Journal of Tissue Engineering and Regenerative Medicine, E-published ahead of print Nov. 8, 2012 (doi:10.1002/term.1643).

  20. Sukarto A, Yu C, Flynn LE, and Amsden BG*. (2012) Co-delivery of adipose-derived stem cells and growth-factor loaded microspheres in RGD-graft N-methacrylate glycol chitosan gels for focal chondral repair. Biomacromolecules 13(8), 2490–2502.

  21. Turner AEB, Yu C, Bianco J, Watkins JF, and Flynn LE*. (2012) The performance of decellularized adipose tissue microcarriers as an inductive substrate for human adipose-derived stem cells. Biomaterials 33(18), 4490-9.

  22. Turner AEB and Flynn LE*. (2012) Design and characterization of porous extracellular matrix-derived microcarriers. Tissue Engineering Part C Methods 18(3), 186-97.

  23. Zhao Y, Waldman SD, and Flynn LE*. (2012) The effect of serial passaging on the proliferation and differentiation of bovine adipose-derived stem cells. Cells Tissues Organs, 195(5), 414-27.

Chapters in Books

  1. Shridhar A, Gilles E, Amsden BG, and Flynn LE*. Composite bioscaffolds incorporating decellularized ECM as a cell-instructive component within hydrogels as in vitro models and cell delivery systems. In Decellularized Scaffolds and Organogensis; Turksen K. Ed.; Methods in Molecular Biology: Springer Protocols, Springer Science+Business Media: New York, 2017; 1-26, doi: 10.1007/7651_2017_36.

  2. Han TTY, Shridhar A, Robb K, Kornmuller A, Brown CFC, and Flynn LE*. Natural materials as smart scaffolds for tissue engineering. In Fundamental Principles of Smart Materials for Tissue Engineering; Wang, Q., Ed. The Royal Society of Chemistry: Cambridge, UK, 2016; 124-7.

  3. Morissette Martin P, Shridhar A, Yu C, Brown CFC, and Flynn LE*. Decellularized adipose tissue scaffolds for soft tissue regeneration and adipose-derived stem/stromal cell delivery. In Adipose-Derived Stem Cells: Methods and Protocols, Second Edition; Bunnell, B. & Gimble, J. Ed.; Methods in Molecular Biology: Springer Protocols, Accepted June 2015, In Press.

  4. Turner AEB and Flynn LE*. Soft tissue regeneration with human adipose-derived stem cells. In Mesenchymal Stem Cells; Xiao, Y., Ed.; Nova Science Publishers, Inc.: New York, 2012; 265-316.

  5. Flynn LE and Woodhouse KA*. Burn dressing biomaterials and tissue engineering. In Biomedical Materials; Narayan, R., Ed.; Springer Science+Business Media: New York, 2009; 371 – 414.