Synthesis and In-vitro Cell Compatibility

Assessment of Poly(amic acid)

 

Introduction

•          Compatibility of biomaterials is affected by polymeric structure and surface properties; surface topography and roughness, chemical structure and functional groups, conformational flexibility, type and density of surface charges etc.

•          Cell compatibility of custom designed and synthesized poly(amic acid) (PAA) evaluated using porcine radial artery cells (RACs).
 
Results

•          RACs seeded onto PAA coated surfaces at a cell density of 7000 cells/cm2.

•          RACs adhere, proliferated and preserved phenotypes.

•          Cell density (72 h)

                - 9781 ± 796 cells/cm2 for the PAA coated

                - 7600 to 7800 cell/cm2 for the controls
 
comtrol PAA paa rac
RACs on uncoated cover slip
(Control)		 PAA PAA coated cover slip
 
Potential Applications

•          Drug eluting stent coating (controlled release)

•          Tissue engineering scaffold
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